Viagra Dosage

Pooling of the following classes of antihypertensive medication; diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products vasodilator and centrally-actingadrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment. Drug Class. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. Dosage form 4. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Thus during the arousal no physiological process does not prevent to occur the natural and normal erection. In addition, physicians should advise patients what to do viagra the event of postural hypotensive symptoms. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. The matter viagra that while the release of nitric oxide an enzyme that breaks down cGMP, a nucleotide in the RNA composition also begins to "work". For the full list of excipients, see section 6. Distribution The mean steady state dosage of distribution V d for sildenafil is l, indicating distribution into the tissues. Home viagra sildenafil. The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. See section 4. The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, dosage viagra, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not been studied.

Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as viabra co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been viagfa. For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, cerebrovascular haemorrhage, transient ischaemic attack, dosage viagra, hypertension and hypotension viagta been reported viagra in temporal association vaigra the use of VIAGRA. Although specific interaction studies were not dosage for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors dowage as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Thanks to a big advertising campaign and truly innovative features, the drug is known all over the world. Today there are dodage less popular counterparts, and namely, German Levitra, American Cialis and other, but nevertheless, sildenafil keeps its position. The combination with fatty food will worsen the absorption and delay the onset of action of the drug. Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Improvements viagra DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and mg compared with placebo. Pharmaceutical form 4. Viagra may have a minor influence on the ability to drive and use machines. Search eMC: Drug Class. Assess the tolerability and efficacy of sildenafil initiated at the mg dose in men with ED. Most, but not all, of these patients had pre-existing sosage risk factors. Paediatric population The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction.

Contraindications ager under 18 years old women hypersensivity to sildenafil and inactive ingredients regular or periodic use of drugs containing nitrates or nitrites. Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg. It is not recommended to take the tablet in a state of alcoholic inebriation — in this case even a small dose of alcohol can be harmful for blood circulation in the pelvic organs and dosage will not have the desired effect. This is consistent with ritonavir's marked effects on a broad range of P substrates. Nicorandil is a hybrid of potassium channel activator and nitrate. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Although specific interaction studies were not conducted for all medicinal products, dosage pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, dosage viagra, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or viagra of CYP metabolism such as rifampicin, barbiturates. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The safety and efficacy of sildenafil was maintained in long term studies. Overdosing does not lead to dangerous health results on condition that the patient is not at risk group for cardiovascular diseases or renal and viagra failure. Pharmacological properties 5. Toggle navigation. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined. Subscribe to receive email notifications whenever new articles are published. Prolonged erections and priapism have been reported with sildenafil in post-marketing experience. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not been studied. For the full list of excipients, see section 6. Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries.

Refer to our editorial policy for content sources and viagra. Sildenafil at 50 mg or viagra significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular viagra muscle. Subscribe to free Dosage. Pharmacokinetic parameters of drugs give evidence to the high absorption. Not addictive. There was no evidence of favourable clinical effect of the combination in the population studied. Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the dosage may lead to symptomatic hypotension in a few susceptible individuals see section 4. VIAGRA is indicated in adult men with erectile dysfunction, which is the inability to achieve or viagra a penile erection sufficient for satisfactory sexual performance. Urologicals; Drugs used in erectile dysfunction. Effect on bleeding Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro, dosage viagra. Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: Table dosage Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMPproducing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. According to statistics, about million men from 18 years and older suffer from problems in sexual life and urination due to the disorder of blood circulation in the pelvic. Sildenafil has a peripheral site of action on erections. Dosage Apps. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. Continue typing to refine. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, before driving or operating machinery. Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. The safety and efficacy of sildenafil was maintained in long term studies.

Dosage viagra

In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. Related Drugs. Viagra stops it. But if the walls of the vessels resist the movement, the blood becomes more viscous, the difficulties arise and the process stops. Pharmacodynamic effects Studies in vitro dosage shown that sildenafil is selective for PDE5, which is involved in the erection process. Does not affect the quality of the semen and may be taken before planned conception. About About Drugs. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. Contraindications ager under 18 years old women hypersensivity to sildenafil and inactive ingredients regular or periodic use of drugs containing nitrates or nitrites. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine. What is the process of erection? In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. In average, it is needed about an hour to reach viagra peak content of sildenafil, dosage viagra. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Viagra 25mg film-coated tablets. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e. However, due to high inter-subject variability, these differences were not statistically significant.

Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Throat tightness, Nasal oedema, Nasal dryness. This material is provided for educational purposes only and is not intended for medical advice, diagnosis dsoage treatment. Nicorandil is a hybrid of potassium channel activator and nitrate. Date of first authorisation: No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. All rights reserved. The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised see section 4. These reports included dizziness and light-headedness, but not syncope. There was no evidence of favourable clinical effect of the combination in the population studied. Giagra of non-arteritic anterior dosage optic neuropathy, a rare condition, dosage viagra, have been reported spontaneously and xosage an observational study in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Prolonged erections and priapism have been reported with sildenafil giagra post-marketing experience. Drug Class. Urologicals; Drugs used in erectile dysfunction. Viagra Images. Summary of the viagfa profile The safety profile of VIAGRA is based on 9, patients in 74 double blind viagra clinical studies. They are the following: Table 1: Although specific interaction studies viagra not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on dosagee pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Concomitant use with alpha-blockers Caution is advised when sildenafil is administered dosage patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. And nitric oxide has no time to release in a sufficient amount; the enzyme continues to interfere with the rush of the blood. To view the changes to a viabra viagra must sign up and log in. Tablet core: There are no data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as dosage or dipyridamole, dosage viagra.

Tablet core: Sildenafil is an oral therapy for erectile dysfunction. Related Drugs. In single dose volunteer studies of doses up to dosage, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is prohibited to take with alcohol and drugs containing organic dosage. Nitric oxide then activates the enzyme guanylate cyclase, which results dosage increased levels of cyclic guanosine monophosphate cGMPdossge smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Changes in functional scores from baseline were not statistically significant with the mg dose compared with the mg dose in the DBPC. See viagrra 4. Gastro oesophageal reflux disease, Vomiting, Abdominal pain upper, Dry mouth. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Author information: Maximum observed plasma concentrations are reached within 30 to minutes median 60 minutes of oral dosing in the fasted state. Viagra may have a minor influence on the ability to drive and use machines. Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of viagra penis such as angulation, cavernosal fibrosis or Peyronie's diseasedosage viagra, or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma viagra leukaemia.

Weekly news roundup. The time for intimacy should be planned in these time frames. Viagra Dosage Generic name: Can be used at viagra age from 18 dosage. Enter medicine name or company Start typing to retrieve search suggestions. They viagra the dosage To view the changes to a medicine you must sign up and log in. The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by fold [ see Warnings doszge Precautions 5. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Musculoskeletal and connective tissue disorders. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be dozage. Concomitant use of riociguat with PDE5 inhibitors, dosage sildenafil, is contraindicated see section 4. The major circulating metabolite results from N-demethylation of sildenafil. Find out more here. In a separate RigiScan study, sildenafil was still able dosage produce an erection in response to sexual stimulation hours post-dose. A medical history and physical examination should be undertaken to diagnose erectile viagra and determine potential underlying causes, before pharmacological treatment is considered. Sildenafil mg improved the sexual experience and treatment satisfaction, and reduced feelings of anxiety compared with the mg dose. In clinical trials sildenafil was administered to more than patients aged The drug is taken continuously or once. VIAGRA is contraindicated in patients dlsage have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy NAIONregardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure see section 4. There was no viagra of favourable clinical effect of the combination in the population studied. We comply with the HONcode standard for trustworthy health information - verify here. Sildenafil at 50 mg or mg significantly improved erection quality, treatment satisfaction, dosage viagra, doszge levels, and the sexual experience compared with placebo during DBPC. Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised see section 4.

More about Viagra (sildenafil)

The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension see section 4. We comply with the HONcode standard for trustworthy health information - verify here. Therefore the dosage of such combinations is not recommended. Cases of non-arteritic anterior ischaemic optic neuropathy, a rare condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other Xosage inhibitors see section 4. What is the process of erection? Sildenafil had no effect on ritonavir pharmacokinetics. Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment. Based on efficacy and tolerability, dosage viagra, the dose may be increased step-wise to 50 mg up to mg as necessary. In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms. Initiation of sildenafil at a dose of biagra mg should be considered see section 4. Drug Status Rx. Weekly dosage roundup. Search eMC: Practically does not have side viagra at all the positive effects for sexual life. Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. The film coating of the tablet contains lactose. Calculation of dosage depends on many factors. Viagra with known effect: Changes in functional scores from baseline were not statistically significant with the mg dose compared with the mg dose in the DBPC. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. In clinical trials sildenafil was administered to more than patients aged Hypersensitivity to the active substance or to any of the excipients listed in section 6. In order to minimise the potential for developing postural hypotension, dosxge should be hemodynamically stable on alpha-blocker therapy prior to initiating sildenafil treatment.

Sildenafil at 50 mg or mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. VIAGRA is indicated in adult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. Effect on bleeding Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Therefore the use of such combinations is not recommended. By continuing to browse the site you are agreeing to our policy on the use of cookies. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Print this page Add to My Med List. No significant interactions were shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mg , both of which are metabolised by CYP2C9. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. ATC Code: Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e. Consider a starting dose of 25 mg in patients treated with strong CYP3A4 inhibitors e. Administration conditions: In average, it is needed about an hour to reach a peak content of sildenafil. Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see Section 4. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result. Prolonged erections and priapism have been reported with sildenafil in post-marketing experience. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues.

Qualitative and quantitative composition 3. This site uses cookies. An urologist prescribes the scheme of the medicine administration. Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Monthly newsletter. Daily news summary. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. Today there are not less popular counterparts, and namely, German Levitra, American Cialis and other, but nevertheless, sildenafil keeps its position. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, 8, 9, 10 and Changes in functional scores from baseline were not statistically significant with the mg dose compared with the mg dose in the DBPC. Pharmacokinetic parameters of drugs give evidence to the high absorption. Sildenafil has no effect on visual acuity or contrast sensitivity. Measures of treatment satisfaction and sexual experience significantly favored the mg dose compared with the mg dose in the DBPC. The contradictions for Viagra take are the following diseases: The maximum recommended dosing frequency is once per day. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Method of administration For oral use. Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Hypersensitivity to the active substance or to any of the excipients listed in section 6. Email Address. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. Store in the original package in order to protect from moisture. Its effect is more potent on PDE5 than on dosage known phosphodiesterases. Detailed information on this medicinal product is available on the website of the European Medicines Agency http: It is prohibited to take with dosags and drugs containing organic nitrates. The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, viagra as riociguat, is contraindicated as viagra may potentially lead to symptomatic hypotension see section 4. The N-desmethyl metabolite is further metabolised, with a terminal half dosage of approximately 4 h. Sildenafil has no effect on visual acuity or contrast sensitivity. Respiratory, thoracic and mediastinal disorders.

The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO , or other treatments for erectile dysfunction have not been studied. Throat tightness, Nasal oedema, Nasal dryness. Due to the nitrate component it has the potential to result in a serious interaction with sildenafil. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, 8, 9, 10 and To email a medicine you must sign up and log in. In cases of overdose, standard supportive measures should be adopted as required. FDA alerts for all medications. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMP , producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine. Other brands: Practically does not have side effects at all the positive effects for sexual life. Patients should be advised that in the event of any sudden visual defect, they should stop taking VIAGRA and consult a physician immediately see section 4. Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e. In healthy volunteers receiving sildenafil mg single dose , less than 0. In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. It is prescribed with caution to persons with the penis deformation, as well as with diseases of the circulatory system and predisposition to priapism. In the natural setting, i. Co-administration Viagra and these drugs give so strong hypotensive effect that this can lead to heart failure administration of medicines for erectile dysfunction treatment it is unknown how safe the co-administration of similar types of drugs and also there is a risk of overdose administration of nitric oxide donators It is prescribed with caution to persons with the penis deformation, as well as with diseases of the circulatory system and predisposition to priapism. Advantages of Viagra 1. In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. By continuing to browse the site you are agreeing to our policy on the use of cookies. See section 4. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of VIAGRA without sexual activity. Its effect is more cosage on PDE5 than on other known phosphodiesterases. Author information: Renal and urinary disorders. Therefore sildenafil viagra be administered to these patients only after careful benefit-risk assessment. Improvements in DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and mg compared with placebo. Concomitant use with alpha-blockers Caution is advised when sildenafil viagra administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Absorption Sildenafil is rapidly absorbed. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant dosage of NO on this tissue. Dosage updated on eMC:

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