[Hypertension Treatment With Nifedipine (Corinfar)]

Views View Edit History. Treatment of angina pectoris mainly vasospastic and chronic stable angina pectoris. In patients with angina pectoris may occur more often, and their duration and intensity may increase, especially at the beginning of treatment. Nifedipine may increase the hypertensive corinfar of antihypertensive drugs that are applied simultaneously, such as: The simultaneous use of nifedipine and tricyclic antidepressants may lead to cirinfar increase in the corinfaf of these drugs in the serum and increase the antihypertensive effect of nifedipine. In applying the drug simultaneously with administration of magnesium sulphate requires careful monitoring corknfar blood pressure due to the possibility corijfar a significant reduction, which may damage the mother and fetus. Keep out of the reach of children. Clinical study, studies the likelihood of interaction of nifedipine and nefazodone, has not yet been conducted. Effect of nifedipine on other drugs Antihypertensive drugs Nifedipine may increase the corinfar effect of antihypertensive drugs that are applied simultaneously, such as: Reproductive system and breast: Antiepileptic drugs that induce the cytochrome P system of ZA4, corinfar, such as phenytoin, carbamazepine and phenobarbital Phenytoin induces the cytochrome P system. In patients with impaired liver function, the metabolism is somewhat slowed down. Use during pregnancy and lactation The use of nifedipine is contraindicated in pregnancy before 20 weeks. The dosage regimen must be determined individually, taking into account the severity of the disease and the patient's response to treatment is applied. This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. From the side of hematopoiesis system and lymphatic system: By corinfar this site, you agree to the Terms of Use and Privacy Policy. Tablets depot should not be separated, as in such a case shielded from the light, guaranteed protective sheath, is no longer guaranteed. Subscribe to receive email notifications whenever new articles are published. Subscribe to free Drugs. Antiepileptic drugs that induce the cytochrome Corinfar system of ZA4, such as phenytoin, carbamazepine and phenobarbital. For further information, including about cookie settings, please read our Cookie Policy.

Keep out of the reach of children. Available for Android and iOS devices. The concentration in the heart muscle was higher than in the skeletal muscles. In some countries this may not be legally possible; if so: Shelf life 3 years. By clicking Subscribe, I agree to the Drugs. The easiest way to corinfar drug information, identify pills, check interactions and set up your own personal medication records. Fluoxetine Clinical study, studies the likelihood of the interaction of nifedipine and fluoxetine, has not yet been conducted. Grapefruit juice inhibits the cytochrome P system. When the following weak or moderate inhibitors of the cytochrome P AP4 system are corinfar simultaneously, it is necessary to control blood pressure and, if necessary, consider reducing the dose of nifedipine. The most important therapeutic measures is to remove the drug from the body and restore stability of functioning of the cardiovascular system. The simultaneous use of nifedipine and tricyclic antidepressants may lead to an increase in the concentration of these drugs in the serum corinfar increase the antihypertensive effect of nifedipine, corinfar. The use of grapefruit juice in the use of nifedipine leads to an increase in the concentration of the drug in the blood plasma and an increase in the duration of action of nifedipine due to a corinfar in metabolism on the first passage or a decrease in clearance. Only a small amount of nifedipine in unchanged form is excreted in the urine. For additional fluid administration should be approached very carefully, corinfar, because it increases the risk of heart overload, corinfar. The ability to influence the reaction rate when driving vehicles or other mechanisms Holding therapy with this drug requires constant medical supervision. Simultaneous reception of nifedipine and magnesium sulfate is not recommended because it is dangerous and can endanger the patient's life. In patients with malignant hypertension and hypovolaemia, hemodialysis, a significant decrease in blood pressure due to vasodilation can occur. It is known that drugs of this class inhibit the cytochrome P system. Corinfar 10 mg tablets Azithromycin, structurally similar to the representatives of the class of macrolide antibiotics, is not inhibited by CYPZA4. An increase in the concentration of nifedipine in blood plasma was reported with the simultaneous use of these drugs, however, no changes in the pharmacokinetics of nifedipine were noted. Formally, no clinical studies have been conducted to study the likelihood of potential interaction between nifedipine and carbamazepine or phenobarbital. In patients with angina pectoris may occur more often, and their duration and corinfar may increase, especially at the beginning of treatment.

Further information

Therapy with cofinfar drug should be stopped gradually, especially where administration of the drug at high doses. In patients taking anticoagulants based on coumarin, after the addition of corinafr, prothrombin time increased. From the side of hematopoiesis system and lymphatic system: After taking nifedipine quickly and almost completely absorbed. In some countries corincar may not be legally possible; if so: Corinfar instructions for use Composition Active substance: Simultaneous corinfar of rifampicin due to the inability to achieve effective levels of nifedipine in blood plasma due to induction of enzymes. The easiest way to lookup drug information, identify pills, corinfar, check corinnfar and set up your own personal medication records. With the simultaneous use of corinfar and quinidine in some cases, a decrease in the level of quinidine, and with the withdrawal of nifedipine - a sharp increase in the concentration of quinidine in the blood plasma. Rifampicin Rifampicin significantly induces the cytochrome P system, corinfar. Since nifedipine is characterized by a high coorinfar of binding to plasma proteins and the relatively small corinfar of distribution, dialysis is not effective, but it is recommended carrying out plasmapheresis. It is known that tacrolimus is metabolized through the cytochrome P system. The use of nifedipine may lead to false-elevated results in the spectrophotometric determination of the concentration of vanilligmugalic acid in the urine however, this effect is not observed corinar using the method of high-performance liquid chromatography. It is not intended as a substitute for the expertise and judgement of your physician, corinfar or other healthcare professional. Packaging 10 tablets in a blister, 3 blisters in a box of 50 or tablets in a bottle, vial 1 in box. Despite this, the use of a combination of nifedipine corinfar rifampicin is contraindicated.

Grapefruit juice inhibits the cytochrome Corinfaf system, corinfar. Jan Arthritis Rheum. Antiepileptic drugs that induce the cytochrome P system of ZA4, such as phenytoin, cornfar and phenobarbital. Corinfar drugs, corinfar weak or moderate inhibitors of the cytochrome P system, and can lead to an increase in the plasma nifedipine concentration, cotinfar, for coronfar With simultaneous use with rifampicin, the bioavailability of nifedipine is significantly reduced and thus cornfar effectiveness is weakened. Studies in animals have shown embryotoxicity, fetotoxicity and teratogenic. Interaction with other drugs and corinfar interactions Drugs affecting the effectiveness of nifedipine. If in vitro fertilization attempts are unsuccessful, in the absence of other explanations, calcium antagonists, in particular nifedipine, can be considered as a possible cause of this phenomenon. Starting and maintenance dose in all cases was 1 tablet 2 times per day. Due to differences individual response to the drug, ability to transport management control mechanisms, perform transactions related body position without support, it is violated. Results appropriate and well-controlled trials of pregnant women lacking the drug. On the part of the psyche: Grapefruit juice corinfar the metabolism of nifedipine, resulting in an increase in its concentration in blood plasma. Corinfar Corknfar may be available in the countries listed below. Patients with a dysfunction of the liver need careful monitoring, and in severe cases, a dose reduction. On the part of the digestive tract: Macrolide antibiotics eg, erythromycin There have been no corinfar of the interaction of nifedipine and macrolide antibiotics. When slowing down the heart rate, life-threatening, it is recommended the use of an artificial pacemaker. Patients with hepatic insufficiency need constant monitoring, may reduce the dose of the drug. Inhibitors of anti-HIV protease eg, ritonavir Clinical study, studies the likelihood of interaction of nifedipine and certain inhibitors of anti-HIV protease, corinfar, has cornfar yet been conducted. Nifedipine dilates the corinfar arteries and reduces the muscle tone of the coronary arteries, thereby increasing the flow of oxygen. Consult with your healthcare professional before taking any medication. Before nonspecific bronchoprovokatsionnym test with methacholine nifedipine should be discarded if possible. The concentration in the heart muscle was higher than in the skeletal muscles, corinfar.

Corinfar

Additional research Cisapride The simultaneous use of cisapride and nifedipine may lead to an increase in the concentration of nifedipine in blood plasma. Despite this, the use of a combination of nifedipine with rifampicin is contraindicated. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment, corinfar. Corinfar taking nifedipine quickly and almost completely absorbed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Patients with hepatic insufficiency need constant monitoring, may reduce the dose of the drug. Tacrolimus It is known that tacrolimus is metabolized through the cytochrome P system. Nefazodone Clinical study, studies the likelihood of interaction of nifedipine and nefazodone, has not yet been conducted, corinfar. Patients with such rare hereditary diseases as galactose intolerance, lactase deficiency or corinfar absorption impairment should not be prescribed. Neither nifedipine nor its metabolites accumulate in the tissues. Clinical study, studies the likelihood of the interaction of nifedipine and fluoxetine, has not yet been conducted. When nifedipine is used along with the following drugs, the degree and duration of the interaction should be taken into account. On the part of metabolism: Shelf life 3 years. If the file has been modified from its original state, corinfar, some details such as the timestamp may not fully reflect those of the original file. Treatment of angina pectoris mainly vasospastic and chronic stable angina pectoris. Antiepileptic drugs that induce the cytochrome P system of ZA4, such as phenytoin, carbamazepine and corinfar Phenytoin induces the cytochrome P system. Separate in vitro experiments have revealed the relationship between the use of calcium antagonists, in particular nifedipine, and reversible biochemical changes in spermatozoa corinfar impair the latter's ability to fertilize.

Therapy with the drug should be stopped gradually, especially where administration of the drug at high doses. Especially at the initial stage of treatment, heart rate and heart volume may grow because of the activation of the baroreceptor reflex, corinfar. Despite this, it can not be ruled out that the concentration of nifedipine in the blood plasma decreases and the effectiveness decreases. Caution should be given to patients on hemodialysis for malignant hypertension or hypovolemia, since the dilatation of the blood vessels can cause a significant reduction in blood corinfar. To a large extent these caveats relating to the initial period of treatment, the period of increasing doses of the drug, when changing to another drug, corinfar. With the simultaneous use of glyceryl trinitrate and isosorbide prolonged action, one should take into account the synergistic effect of nifedipine. Patients with such rare hereditary diseases as galactose intolerance, lactase deficiency or glucose-galactose absorption impairment should not be prescribed, corinfar. Jan Arthritis Rheum. Results appropriate and well-controlled trials of pregnant women lacking the drug. Overdose The symptoms of acute intoxication: Retrieved from " https: There have been no studies of the interaction of nifedipine and macrolide antibiotics. Neither nifedipine nor its metabolites accumulate in the tissues. Since nifedipine is characterized by a high degree of binding to plasma proteins and the relatively small volume corinfar distribution, dialysis is not effective, but it is recommended carrying out plasmapheresis. Dosing and Administration The dosage regimen must be determined individually, taking into account the severity of the disease and the patient's response to treatment is applied. From the nervous system: Valproic corinfar A formal clinical study, studying the likelihood of interaction of nifedipine and valproic acid, has not yet been conducted. Despite this, with the simultaneous use or withdrawal corinfar nifedipine, it is recommended to monitor the concentration of quinidine in the blood plasma, and, if necessary, to adjust the dose of quinidine. Separate in vitro experiments have revealed the relationship between the use of calcium antagonists, in particular nifedipine, and reversible biochemical changes in spermatozoa that impair the latter's ability to fertilize. Corinfar published data indicate that in some cases the dose of tacrolimus can be reduced with simultaneous application with nifedipine. Inhibitors of anti-HIV protease eg, ritonavir Clinical study, studies the likelihood of corinfar of nifedipine and certain inhibitors of anti-HIV protease, has not yet been corinfar. After oral administration is recommended to completely empty stomach, optionally in combination with small intestinal washing. Use during pregnancy and lactation The use of nifedipine is contraindicated in pregnancy before 20 weeks.

In some countries this corinfar not be legally possible; if so: When nifedipine is used along with the following drugs, the degree and duration of the interaction should be taken into account. Neither nifedipine nor its metabolites accumulate in the tissues. Before nonspecific bronchoprovokatsionnym test with methacholine nifedipine should be discarded if possible. With simultaneous corrinfar with nifedipine, a significant increase in the concentration of nifedipine in the corijfar plasma can not be excluded due to a decrease in metabolism during the first passage and a decrease in the rate of excretion from the body. Most researchers use their institutional email address as their ResearchGate login. Caution should be given to patients on hemodialysis for malignant hypertension or hypovolemia, since the dilatation of the blood vessels can cause a significant reduction in blood pressure. Patients with Prinzmetal angina vasospastic the daily dose can be increased to a maximum of 60 mg. To a large extent these caveats relating to the initial period corinfar treatment, corinfar, the period of increasing doses of the drug, when changing to another drug. Indications Treatment of arterial hypertension. By using this site, you agree to the Terms of Use and Privacy Policy. With simultaneous use with rifampicin, the bioavailability of nifedipine is significantly reduced and thus its effectiveness is weakened. Coriinfar in animals have shown embryotoxicity, fetotoxicity and teratogenic. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances, corinfar. Eating together with a corinfar slows down, corinfzr does not decrease absorption. The simultaneous use of nifedipine and tricyclic antidepressants may lead to an increase in the concentration of these drugs in the serum and increase the antihypertensive effect of nifedipine. Category of leave On prescription. Structured data Captions English Add a corinfar explanation of what this file represents. If calcium administering underperforms, appropriate use of dopamine, dobutamine, epinephrine, or norepinephrine, corinfar. Nefazodone Clinical study, studies the likelihood of interaction of nifedipine and nefazodone, has not yet been conducted. Dosing and Administration Corinfar dosage regimen must be determined individually, taking into account the severity of the disease and the patient's response to treatment is applied. Clinical study, studies the likelihood of the interaction of nifedipine and fluoxetine, has not yet been conducted. In patients with impaired liver function, the metabolism is somewhat slowed down. Rifampicin significantly induces the cytochrome P system.

Especially at corinfar initial stage of treatment, heart rate and heart volume may grow because of the activation of the baroreceptor reflex. This page was last edited on 1 Septembercorinfar, at Corinfar Corinfar may be available in the countries listed below. Jan Arthritis Rheum. In addition, drugs of this class inhibit in vitro a cytochrome Pmediated system of N4 metabolism of nifedipine. Hide publication data in Russian. Before nonspecific bronchoprovokatsionnym test with methacholine nifedipine should be discarded if possible. From the side of hematopoiesis system and lymphatic system: A formal clinical study, investigating the likelihood of interaction of nifedipine and certain azole antimycotics, has not yet been conducted. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. With severe arterial hypotension systolic pressure below 90 mm Hg. Indications Treatment of arterial hypertension. In patients with impaired liver function, the metabolism is somewhat slowed down. On the part corinfar the digestive tract: Studies in animals have shown that the released nifedipine is distributed to all organs and tissues. The use of nifedipine may lead to false-elevated results in the spectrophotometric determination of the concentration of vanilligmugalic corinfar in the urine however, this effect is not observed when using the method of high-performance liquid chromatography. The drug should be taken with liquid, after eating, drinking plenty of fluids except grapefruit juicepreferably in the morning and in the evening corinfar one corinfar the same time. Clinical study, studies the likelihood of the interaction of nifedipine and fluoxetine, has not yet been conducted.

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Additional research Cisapride The simultaneous use of cisapride and nifedipine may lead to an increase in the concentration of corinfar in blood plasma. The use of grapefruit juice in the use of nifedipine leads to an increase in the concentration of the drug in the blood plasma and an increase in the duration of action of nifedipine due to a decrease in metabolism on the corinfar passage or a decrease in clearance. Corinfar simultaneous use with nifedipine, corinfar, a significant increase in the concentration of nifedipine in the blood plasma can not be excluded due to a decrease in metabolism during the first passage and a decrease in the rate of excretion from the body. Formally, no clinical studies have been conducted corinfar study the likelihood of potential interaction between nifedipine and carbamazepine or phenobarbital. Therefore, drugs that inhibit or induce this enzyme system can change the "first pass" after oral administration or the clearance of nifedipine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Jan Arthritis Rheum. The drug should not be used in patients with ileo-intestinal reservoir ileostomy after proctocolectomy. The significance of this interaction has not been fully explored. From the digestive system: If necessary, reduce the corinfar of nifedipine. In isolated cases, obstructive symptoms have corinfar described in the absence of an abnormality in the gastrointestinal tract. For additional fluid administration should be approached very carefully, because it increases the risk of heart overload. Antiepileptic drugs that induce the cytochrome P system of ZA4, such as phenytoin, carbamazepine and phenobarbital Phenytoin induces the cytochrome P system. I grant anyone the right to use this work for any purposewithout any coribfar, unless such conditions are corinfar by law. With the simultaneous administration of vincristine corinfar there is a weakening of vincristine, a decrease in the dose of cephalosporins - an corinfar in coringar level of cephalosporin in the corinfqr plasma. Views View Edit History.

Ingredient matches for Corinfar

In patients taking anticoagulants based on coumarin, after the addition of nifedipine, prothrombin time increased. Nifedipine can alter the bronchial reactivity of methacholine. Clinical study, studies the likelihood of interaction of nifedipine and certain inhibitors of anti-HIV protease, has not yet been conducted. Side effects were recorded in 6 patients, but the drug was discontinued only in 2 patients because of the allergic reactions. Teva Pharmaceutical Industries Pharmaceutical product packaging Nifedipine. Permission Reusing this file. The significance of this interaction has not been fully explored. Changes in the blood count, anemia, leukopenia, thrombocytopenia, and thrombotic microangiopathy, agranulocytosis, thrombocytopenic purpura. Application features With severe arterial hypotension systolic pressure below 90 mm Hg. Nifedipine can lead to a toxic effect of magnesium sulfate, which is the cause of neuromuscular blockade. The drug should be taken with liquid, after eating, drinking plenty of fluids except grapefruit juice , preferably in the morning and in the evening at one and the same time. Reproductive system and breast: Phenytoin induces the cytochrome P system. Holding therapy with this drug requires constant medical supervision. The use of grapefruit juice in the use of nifedipine leads to an increase in the concentration of the drug in the blood plasma and an increase in the duration of action of nifedipine due to a decrease in metabolism on the first passage or a decrease in clearance. Depending on the individual clinical picture, the recommended dose should be increased gradually. Grapefruit juice inhibits the metabolism of nifedipine, resulting in an increase in its concentration in blood plasma. In the case of increasing the dose of nifedipine with the simultaneous use of these drugs with the withdrawal of phenytoin should consider reducing the dose of nifedipine. Digoxin, Theophylline With the simultaneous administration of nifedipine with theophylline or digoxin, the concentration of theophylline or digoxin in serum can increase. Especially at the initial stage of treatment, heart rate and heart volume may grow because of the activation of the baroreceptor reflex. To a large extent these caveats relating to the initial period of treatment, the period of increasing doses of the drug, when changing to another drug. Tacrolimus It is known that tacrolimus is metabolized through the cytochrome P system. With the simultaneous use of these drugs, it is necessary to monitor the clinical response to nifedipine therapy and, if necessary, to consider increasing the dose of nifedipine. At the same time, it reduces the overall peripheral resistance of the vessels afterload , thereby relieving the heart. The clinical effect was manifested by a decrease in the rate, duration and intensity of RS attacks.

Nifedipine should be administered with caution to patients who are already taking cimetidine, and its dosage should be increased more gradually. Due to differences individual response to the drug, ability to transport management control mechanisms, perform transactions related body position without support, it is violated. Contraindications Hypersensitivity to nifedipine or to any other component of the drug; Cardiogenic shock Simultaneous reception of rifampicin due to the inability to achieve effective levels of nifedipine in blood plasma due to induction of enzymes Unstable angina Acute myocardial infarction within the first 4 weeks Aortic stenosis of high degree; Ileostomy or colostomy. There have been no studies of the interaction of nifedipine and macrolide antibiotics. Azole antimycotics for example, ketoconazole A formal clinical study, investigating the likelihood of interaction of nifedipine and certain azole antimycotics, has not yet been conducted. Interaction with other drugs and other interactions Drugs affecting the effectiveness of nifedipine. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. On the part of the digestive tract: Therefore, drugs that inhibit or induce this enzyme system can change the "first pass" after oral administration or the clearance of nifedipine. Retrieved from " https: With simultaneous use with nifedipine, a significant increase in the concentration of nifedipine in the blood plasma can not be excluded due to a decrease in metabolism during the first passage and a decrease in the rate of excretion from the body. With the simultaneous use of these drugs can not exclude an increase in the concentration of nifedipine in blood plasma. I grant anyone the right to use this work for any purpose , without any conditions, unless such conditions are required by law. Diltiazem weakens the decomposition of nifedipine, which can cause a decrease in dose. Side effects were recorded in 6 patients, but the drug was discontinued only in 2 patients because of the allergic reactions. In some countries this may not be legally possible; if so: There corinfar been no studies of the interaction of nifedipine and macrolide antibiotics. Separate in vitro experiments have revealed the relationship between the use of calcium antagonists, corinfar, in particular nifedipine, and reversible biochemical changes in spermatozoa that impair the latter's ability to fertilize.

Changes in the blood count, anemia, leukopenia, thrombocytopenia, and thrombotic microangiopathy, agranulocytosis, thrombocytopenic purpura. Subscribe to receive email notifications whenever new articles are published. Nifedipine is metabolized through the cytochrome P system, 4A4, therefore, drugs that inhibit or induce this enzyme system can change the "first pass" or clearance of nifedipine. With the simultaneous use of nifedipine and quinidine in some cases, a decrease in the level of quinidine, and with the withdrawal of nifedipine - a sharp increase in the concentration of quinidine in the blood plasma. Very rare may arise Bezoar, which may require surgical intervention. Interaction with other drugs and other interactions Drugs affecting the effectiveness of nifedipine. The clinical effect was manifested by a decrease in the rate, duration and intensity of RS attacks. In cases of intoxication caused by sustained release drugs, efforts should be made to the fullest possible excretion of the drug, including the small intestine to prevent the absorption of the active ingredient. Caution should be given to patients on hemodialysis for malignant hypertension or hypovolemia, since the dilatation of the blood vessels can cause a significant reduction in blood pressure. Before nonspecific bronchoprovokatsionnym test with methacholine nifedipine should be discarded if possible. From Wikimedia Commons, the free media repository. Antiepileptic drugs that induce the cytochrome P system of ZA4, such as phenytoin, carbamazepine and phenobarbital Phenytoin induces the cytochrome P system. Effect of nifedipine on other drugs Antihypertensive drugs Nifedipine may increase the hypertensive effect of antihypertensive drugs that are applied simultaneously, such as: The simultaneous use of cisapride and nifedipine may lead to an increase in the concentration of nifedipine in blood plasma. Despite this, with the simultaneous use or withdrawal of nifedipine, it is recommended to monitor the concentration of quinidine in the blood plasma, and, if necessary, to adjust the dose of quinidine. With the simultaneous use of these drugs, it is necessary to monitor the clinical response to nifedipine therapy and, if necessary, to consider increasing the dose of nifedipine. Starting and maintenance dose in all cases was 1 tablet 2 times per day. In the case of increasing the dose of nifedipine with the simultaneous use of these drugs with the withdrawal of phenytoin should consider reducing the dose of nifedipine. On the part of the kidney and urinary tract: Selective calcium antagonists with a predominant effect on blood vessels. Side effects were recorded in 6 patients, but the drug was discontinued only in 2 patients because of the allergic reactions. The ability to influence the reaction rate when driving vehicles or other mechanisms Holding therapy with this drug requires constant medical supervision. Home International Corinfar Print Share. Neither nifedipine nor its metabolites accumulate in the tissues.