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Canada also has an opportunity to be a global leader in certain new growth areas. Return to footnote 16 referrer. Sandoz, the second largest global generic drug company operates an employee facility in Boucherville QC, specializing in injectables for its global family. Return to footnote 14 referrer. New products launched in accounted for canaxian-pharma. Consequently, companies will continue to expand outsourcing strategies, relying on CSPs or partners. The impetus for MNEs to outsource their functions is based on several canadian-pharma. MNEs canadian-pharma, whether they are brand manufacturers or global CSPsweigh their investment decision based on revenue canadian-pharma profit as a function of pricing, market access and size, local advantages, resources and proximity to end users. However over the past several years due to challenges within the global economy and canadian-pharma biopharma industry, the Canadian industry has struggled to transition SMEs and their early-stage research into viable commercial positions. Return to footnote 35 referrer. The company, with its core business of drug discovery and development, has developed significant income-generating partnerships with global Canadian-pharma such as Roche, Novartis, Merck, Takeda and Teva. Return to footnote 27 referrer. Biological Response Modifiers are anti- TNF monoclonal antibody biologics for the treatment of diseases associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis, hidradenitis suppurativa and canadian-phara asthma. This SWOT analysis considers these factors for the four segments of companies within the pharmaceutical industry in Canada. Several other policies by payers that will affect the industry include:. Slowing global growth continues inat a pace of 3. In Canada, SEBs cannot be declared as interchangeable with an original biologic, canadian-pharma. In Footnote 1the Canadian market canadian-pharma the 8th largest in the world and accounted for 2. Several biologic drugs will lose patent protection during the period. Return to footnote 17 referrer. Canadiqn-pharma back to over 6, fully searchable News stories dating from

Canadian Drug Stores and Hospital Puchases In this study, these brands retained a higher share of their sales after loss of exclusivity. Global pharmaceutical companies are shifting production to emerging markets for cost savings and to gain access to fast growing demand in these markets. The CDH contains national and provincial estimates of sales volumes of dollars and units of pharmaceutical products purchased by retail pharmacies and hospitals. Canadian market performance of the generic segment is anticipated to remain weak during the short term canadiann-pharma another wave of patent expiries inas further reforms by public and private drug plans are phased in. Verified online pharmacies display the PharmacyChecker seal on their websites. Return to footnote 34 referrer. Return to footnote 3 referrer. Drawing on the current and prospective outlook assessment of the industry, the discussion paper undertakes a SWOT analysis discussing future prospects, threats and opportunities facing the industry. Bycanadian-pharma top 10 still consisted of two generic companies but with Novopharm wholly owned by foreign-owned Teva, canadian-pharma. To learn more about each pharmacy, canadian-pharma, canadian-pharma on the "view pharmacy" profile link. Return to footnote 61 referrer Footnote 62 Industry Canada research Return to footnote 62 referrer Footnote 63 http: IMS anticipates the leading products in the global market place will be specialty products and biologics in the area of oncology, autoimmune, antivirals, immunostimulants, immunosuppressants and multiple sclerosis Footnote For MNEsalliances with, or acquisitions of biopharma SMEs with promising product pipelines are avenues to address their low pipeline productivity. While many companies sell canadia-pharma the Canadian market, the majority of these companies are headquartered outside Canada. Return to footnote 56 referrer. Ranbaxy, an India-based company is a top generic selling company in Canada came under the danadian-pharma of Canadian-pharma pharmaceutical company, Daiichi Sankyo in Teva, Apotex, Pharmascience and its division Pendopharm, and Sandoz. Return to footnote 9 referrer. Generally, Canadian-based canadian-pharma in the industry are relatively smaller and serve niche specialty segments of the industry. The company's manufacturing plant in Brandon manufactures the raw material intermediate for caadian-pharma Premarin brand which is the largest pharmaceutical product export in Canada. CDH purchase dollars and units are presented by retail, hospital and total purchases at the following levels:. Brazil and China posted growth of

Canada’s pharmaceutical industry and prospects

Based canadian-pharma current trends, the Canadian market is on a falling trajectory out of the top 10 leading markets as such Canada's clout as a global player is declining. Several examples of such rationalizing include: MNEs with operations in Canada have and are responding to market conditions and competitive global corporate dynamics by rationalizing and reducing their level of direct investment. Return to footnote 63 referrer. For canadian-pharma to reproduce the information in this publication for commercial redistribution, please contact:. The two main positive drivers of growth in the medium term will b e launches of expensive innovative and specialty drugs, and the expansion of access to primary healthcare services that will increase sales volume. The commercial attractiveness of a canadian-pharma is influenced by the extent of uptake and utilization, price regulation, the degree of access to public and private drug canadian-pharma and intellectual property policy. While many companies sell into the Canadian market, the majority of these companies are headquartered outside Canada. Emerging markets will drive overall global expansion and they will continue to gain sales volume and market share. The top 10 brand products inin terms of volume accounted for The company's manufacturing plant in Brandon manufactures the raw material intermediate for its Premarin brand which is the largest canadian-pharma product export in Canada. Montreal-based Enobia specialized in developing novel therapeutics for bone disorders and its enzyme replacement therapy ENB received orphan canadian-pharma in the US and the EU in These pressures include but are not canadian-pharma to an unprecedented expiration of patents for many blockbuster drugs, often referred to as the patent cliff, and on-going cost containment measures from both public and private payers. IMS World Review provides information about market trends and offers breakdown of sales by country, by therapy classes and products. Canadian-pharma collaboration as part of the Health Care Innovation Working Groupof the Council of Federation—an intergovernmental secretariat comprising of Canadian premiers, canadian-pharma. Return to footnote 31 referrer. The response to conditions in the global industry since has been an onslaught of mergers and acquisitions as companies sought to consolidate their cost base, expand research pipelines and broaden their geographic market reach.

However over the past several years due to challenges within the global economy and the biopharma industry, the Canadian industry has struggled to transition SMEs and their early-stage research into viable commercial positions. Return to footnote 49 referrer. The commercial attractiveness of a product is influenced by the extent of uptake and utilization, price regulation, the degree of access to public and private drug plans and intellectual property policy. Both these acquisitions canadian-pharma motivated by the acquirers' quest to enhance their underperforming product pipelines. Return to footnote 17 referrer Footnote 18 Fraser Institute. IMS Knowledge Link offers a distinct advantage; enables users to gather a wealth of information from one place canadian-pharma. Return to footnote 53 referrer, canadian-pharma. Footnote 26 Although MNEs are reducing their level of direct investment, their spending in terms of outsourcing the manufacturing function has benefited the CSP segment. Generally, Canadian-based companies in the industry are relatively smaller and serve niche specialty segments of the industry. Biopharma SMEs are challenged in raising capital and cite the regulatory process as an added hindrance. In the US, the FDA issued guidelines in February providing new biotech drugs a year period of exclusivity and requiring generic manufacturers to submit extensive chemical and biological testing data. Amongst the leading brand MNEs by their sales in the Canadian market, the following company have a manufacturing footprint in Canada: Market growth in Canada and in developed markets will continue to canadian-pharma outpaced by fast growing emerging markets see Figure 8. For brand companies, genericization erodes the margins of branded products. Waiting for New Medicines in Canada. SWOT analysis of the Canadian industry. Biotechnology drugs as defined in IMS PharmaFocus reports include products pharmaceutical or vaccine that canadian-pharma been produced in living organisms and manufactured via recombinant DNA technology. Pharmaceutical companies fund the development of new drug products with the profits from current products and future revenue stream. The discussion paper is organized into three main sections, canadian-pharma. Biological Response Modifiers are anti- TNF monoclonal antibody biologics for the treatment of diseases associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis, hidradenitis suppurativa and refractory asthma. Sales growth slowed significantly by In Cangene merged with Apotex subsidiary Rh Pharmaceuticals. Canadian Drug Stores and Hospital Puchases Return to footnote 25 referrer.

Canadian-pharma

In Canadian-pharma merged with Apotex subsidiary Rh Pharmaceuticals. Return to footnote 14 referrer. Generic companies manufacture and market lower-priced generics once patents of branded products expire. Some generic companies also encountered manufacturing issues because they were unable to access active ingredients, leading to difficulties canadian-pharma to their customers. Pricing and Reimbursement News: Canadian-pharma learn more about each pharmacy, click on the "view pharmacy" profile link, canadian-pharma. Year 2 for group of new products is Jan-Dec Return to footnote 53 referrer. Payers seeking lower cost medicine shifted the market canadian-pharma towards the generic segment and more recently the latest round of provincial drug plan reforms have drastically cut generic prices in most provinces. Return to footnote 19 referrer. For permission to canadian-pharma the information in this publication for commercial redistribution, please contact:. Due to the genericization of key brands, several of the leading therapeutic classes are experiencing weak or negative growth in and so far in Roche is now in the top 10, largely due to its strength in the fast growing speciality segment. In the US, the FDA issued guidelines in February providing new biotech drugs a year period of exclusivity and requiring generic manufacturers to submit extensive chemical and biological testing data. Return to footnote 49 referrer. Footnote 19 The recent slowdown in the Canadian generic market is reflected in the performance of leading generic companies. Developing personalized medicines is resource-intensive, requiring canadian-pharma to leverage multiple partners. These niche areas typically have small number of patients. Figure 5 illustrates the changing composition of the leading companies in Canada. Canada's pharmaceutical industry consists of an ecosystem of multinational and local companies. The evolution and growing dominance of biologics along with MNEs ' desire to improve their pipeline productivity has meant that biopharma SMEs in Canada have an opportunity to flourish. Global pharmaceutical companies are shifting production to emerging markets for cost savings and to gain access to fast growing demand in canadian-pharma markets. Return to footnote 20 canadian-pharma. IMS World Review provides information about market trends and offers breakdown of sales by country, by therapy classes and products. Canadian market performance of the generic segment is anticipated to remain weak during the short term despite another wave of patent expiries inas further reforms by public and private drug plans are phased in.

Several other policies by payers that will affect the industry include:. For brand companies, genericization erodes the margins of branded products. Most major branded pharmaceutical companies are foreign multinationals with subsidiaries in Canada. Ironically, for many Canadian biopharma SMEs the typical success path is to be acquired. Canadian-pharma 16 Amongst the top 10 corporations based on their Canadian sales, Pfizer and GlaxoSmithKline were the two corporations that experienced negative growth in The canadian-pharma corporations in Canada in had posted a four-year compound annual growth of 8. The new Valeant is building its product pipeline through acquisitions, in part to counter declining sales and genericization of its key products. CSPs have specialized capacity thus typically have lower costs than larger and integrated pharmaceutical MNEs. IMS Knowledge Link offers a distinct advantage; enables users to gather a wealth of canadian-pharma from one place instantaneously:. There are over canadian-pharma pharmaceutical CROs operating in Canada mostly providing services in pre-clinical research and conducting clinical trials. Following the introduction 2. IMS anticipates the leading products in the global market place will be specialty products and biologics in the area of oncology, autoimmune, antivirals, immunostimulants, immunosuppressants and multiple sclerosis Footnote Market access levels in public drug plans have also been persistently low. Four-year CAGR was 3. Commercial Reproduction Reproduction of materials in this document, in whole or in part, for the purposes of commercial redistribution is prohibited except with written permission from IMS Brogan, canadian-pharma. Canada's larger pharmaceutical companies include Apotex and Pharmascience. Inthe top 10 brands accounted for Footnote 40 Biopharma SMEs canadian-pharma Canada have difficulty attracting venture capital because of weak returns from initial public offerings IPOs and cumbersome regulatory processes. These strategies include adopting new business models built upon external networks and third party partnerships focused on medical research and development. Within clinical research, Phase III typically receives the largest proportion of clinical research spending. Return to footnote 28 referrer. In this study, these brands retained a higher share of their sales after loss of exclusivity. Upon completion, the combined company retained the Valeant name.

Footnotes Footnote 1 Latest canadian-pharma year annual data available at time of writing Return to footnote 1 referrer Footnote 2 Specialty pharmaceuticals are medicines that treat specific, complex chronic diseases with canadian-pharma or more of the following attr ibutes: Return to footnote 60 canadian-pnarma. Generally, Canadian-based companies in the industry are relatively smaller and canadian-pharmq niche specialty segments of the industry, canadian-pharma. The contrast to this innovation in biologics is patent expiry precipitating record levels of revenue losses for brand products and triggering the expansion of the generic sector, globally and in Canada. Companies will continue seeking opportunities to strengthen their core areas and allocate their resources to these areas and to growing markets. Footnote 19 The recent slowdown in the Canadian generic market is reflected in the performance of leading generic companies. Brazil and China posted growth of Return to footnote 8 referrer. Since the heightened period of the patent cliff inthe global pharmaceutical industry has faced substantial revenue and cost pressures. A recent retrospective study on a sample of older top selling brand products that recently canadian-pharma exclusivity, observed that despite a shorter patent protection policy, Canada is an attractive market relative to the US and several EU countries. SWOT analysis of the Canadian industry. Some companies in the Canadian-pharma industry are cxnadian-pharma into innovative avenues, alliances and partners to fund and reduce the cost risk associated with developing products and expanding their pipeline. In the US, the FDA issued guidelines in February providing new biotech drugs a year period of exclusivity and requiring generic manufacturers to submit extensive chemical and biological danadian-pharma data. Return to footnote 5 referrer. Return to footnote 29 referrer. The Canadian generic sector posted strong growth throughout much of the last decade however, by the sector began to face strong headwinds, namely from lower generic pricing policies introduced in public and private drug plans. This contrast in growth has forced many global MNEs to focus their investment and efforts in the higher growth emerging countries, canadian-pharma in turn is making it more competitive for MNEs to increase or even maintain their investment in Canada. In Canada, canadian-pharma, SEBs cannot be declared as interchangeable with an original biologic. Several examples of such rationalizing include:

Return to footnote 3 referrer. This model recently led to the first novel gene therapy treatment approved in a developed market orphan disease lipoprotein lipase deficiency. In Canada, federal and provincial governments are supporting this area through funding commitments. This SWOT analysis is applied at an industry level so the internal factors classified as strengths or weaknesses will be at the industry level while external factors classified as opportunities or threats will be along the broader operating environment for the industry in Canada. The company, with its core business of drug discovery and development, has developed significant income-generating partnerships with global MNEs such as Roche, Novartis, Merck, Takeda and Teva. Emerging markets will drive overall global expansion and they will continue to gain sales volume and market share. Through the first half of for example, 11 new molecular entities were launched in the global market, all of which are specialty products. While recent pharmaceutical industry trends in Canada have been challenged with poor market growth and pressures from global competition, there still remains a very viable industry which if aided by stronger industrial sector support can flourish and successfully compete in this new and much more globally competitive business environment. Return to footnote 64 referrer. Return to footnote 13 referrer Footnote 14 Source: Market segments driving the Canadian pharmaceutical market also reflect considerable changes and contrasts in growth. In addition to the patent cliff, other key events anticipated to affect the medium term performance of the Canadian market include the end of Quebec's Bap rule which provided formulary access of 15 years for brand products, and the breadth of generic pricing reforms by public and private payers. Based on current trends, the Canadian market is on a falling trajectory out of the top 10 leading markets as such Canada's clout as a global player is declining. Return to footnote 3 referrer Footnote 4 Biological Response Modifiers are anti- TNF monoclonal antibody biologics for the treatment of diseases associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis, hidradenitis suppurativa and refractory asthma. These fast growing companies include Shire, Lundbeck, BMS-Gilead and Nycomed now part of Takeda are predominantly smaller companies focused on niche and specialty products. The slowing trend is noteworthy along with the stark contrast that makes up this overall growth: The evolution and growing dominance of biologics along with MNEs ' desire to improve their pipeline productivity has meant that biopharma SMEs in Canada have an opportunity to flourish. Similar to this contrast in geographical performance are the large differences in the drivers of growth in therapeutic areas. In , this share was To visit a pharmacy listed below, click on its logo. Canada's pharmaceutical industry consists of an ecosystem of multinational and local companies.

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The overall Canadian market is expected to experience on-going challenges and uncertainties until which will weigh on corporate performances. Return to footnote 12 referrer. The top corporations in Canada in had posted a four-year compound annual growth of 8. Within clinical research, Phase III typically receives the largest proportion of clinical research spending. This discussion paper does not examine the Canadian distribution channels. Return to footnote 37 referrer. Return to footnote 58 referrer. IMS Knowledge Link offers a distinct advantage; enables users to gather a wealth of information from one place instantaneously:. Outsourcing low margin products enables companies to control and optimize costs. The company, with its core business of drug discovery and development, has developed significant income-generating partnerships with global MNEs such as Roche, Novartis, Merck, Takeda and Teva. IMS World Review provides information about market trends and offers breakdown of sales by country, by therapy classes and products. More recently, the fasting growing companies, in terms of Canadian sales, are companies outside the list of the top 10 in Figure 5. CSPs have specialized capacity thus typically have lower costs than larger and integrated pharmaceutical MNEs. Moreover, in challenging markets where demand is increasingly volatile, outsourcing business functions enable MNEs to respond swiftly to changing conditions without cumbersome efforts in adjusting their operational capacity, so that they can focus on innovation and their core functions. However, the number of clinical trials received in Canada has declined since from 1, to 1, trials received in

Pfizer reduced its global workforce by 10, between and All these brands have now been genericized. Return to footnote 29 referrer. Coinciding with the heightening of the patent cliff, was the first time in the Canadian pharmaceutical industry that two generic companies were amongst the top 10 corporations: Monthly Pharma Pricing and Reimbursement Magazine: Canada's larger pharmaceutical companies include Apotex and Pharmascience. Conditions of attractive markets include investment infrastructure and government incentives such as taxation. The discussion paper is organized into three main sections. However the dollar values of these investment incentives are small relative to investments by governments in other countries. Biopharma SMEs are challenged in raising capital and cite the regulatory process as an added hindrance. Return to footnote 17 referrer Footnote 18 Fraser Institute. The acquisition was intended to improve their financial position and cost structure, and significantly expand their presence in key North America product markets. Return to footnote 40 referrer. A recent retrospective study on a sample of older top selling brand products that recently ended exclusivity, observed that despite a shorter patent protection policy, Canada is an attractive market relative to the US and several EU countries. The paper highlights the medium term outlook for the industry, identifying key factors that shape the industry in coming years. Footnote 32 The emergence of low cost clinical research competitors from emerging markets and their improving quality, combined with increasing hospital and academic overhead charges in Canada and the strong Canadian dollar will continue to challenge Canada's advantage in clinical research. Return to footnote 19 referrer. Increasingly, MNEs are changing their business model by focusing on growing specialty therapeutic areas and diversifying to different geographic markets through acquisitions and alliances. In recent years, program support for the industry has been geared towards specialty areas and biotech products. The supply issue amongst generic manufacturers occurred in Canada, US and other parts of the world. The CDH is available monthly and includes a rolling 71 months of history. Developing personalized medicines is resource-intensive, requiring companies to leverage multiple partners. Conditions of attractive markets include investment infrastructure and government incentives such as taxation. The compound annual growth of the top 10 corporation, based on their sales, was 3. The patent cliff and challenging market conditions combined with low pipeline productivity of MNEs acted as catalysts for canadian-pharma transformation of the business model of MNEs. Return to canadian-phaarma 35 referrer. Canadian Drug Stores and Hospital Puchases

Since the heightened period of the patent cliff in , the global pharmaceutical industry has faced substantial revenue and cost pressures. There are over 80 pharmaceutical CROs operating in Canada mostly providing services in pre-clinical research and conducting clinical trials. MNEs , whether they are brand manufacturers or global CSPs , weigh their investment decision based on revenue and profit as a function of pricing, market access and size, local advantages, resources and proximity to end users. The Biotech market segment includes some oncology products. The generic segment is a mix of Canadian-based and foreign MNEs and smaller companies. Emerging markets will drive overall global expansion and they will continue to gain sales volume and market share. Mergers and acquisitions can provide scale advantages in targeted areas, access to large or growing markets and additions to product pipeline. Slowing global growth continues in , at a pace of 3. For example, new products launched in the Canadian market in accounted for 0. Return to footnote 28 referrer. Outlook Through ", IMS Institute for Healthcare Informatics July Biologics treat a wide breadth of therapeutic areas and products considered biologics are also classified in under other therapeutic classes For example, certain products in oncology and insulin classes are considered biologics. This contrast in growth has forced many global MNEs to focus their investment and efforts in the higher growth emerging countries, which in turn is making it more competitive for MNEs to increase or even maintain their investment in Canada. Footnote 40 Biopharma SMEs in Canada have difficulty attracting venture capital because of weak returns from initial public offerings IPOs and cumbersome regulatory processes. Biopharma SMEs are challenged in raising capital and cite the regulatory process as an added hindrance. Nonetheless with intensifying international competition, CSPs based in Canada will seek to differentiate themselves in providing quality and through advantages of scale in their services to appeal to and meet demands of global MNEs. Pfizer operates a manufacturing facility and distribution center employing over 1, in Montreal. Pricing and Reimbursement News: Footnote 26 Although MNEs are reducing their level of direct investment, their spending in terms of outsourcing the manufacturing function canadian-oharma benefited the CSP segment. Footnote 11 Cobalt operated a manufacturing facility in Mississauga but announced the shutdown of this facility by after it was acquired by US-based Watson Pharmaceutical Inc. In recent years, program support for the industry has been geared towards specialty areas and biotech products. Return to footnote 13 referrer Footnote 14 Source: Canadisn-pharma seeking lower cost medicine shifted the market share towards the generic segment and more recently the latest round of provincial drug plan reforms have drastically cut generic prices in most provinces. Drawing on the current and prospective outlook assessment canaian-pharma the industry, the discussion paper undertakes a SWOT analysis discussing future prospects, threats and opportunities facing the industry. There have been fewer innovative product launches and the uptake of new products has not sufficiently offset revenue loss from patent expiries. Return to footnote 59 referrer.